Nomenclature for Tryptophan Biosynthetic Pathway

Rules of Nomenclature

Key to nomenclature^aused for tryptophan biosynthetic pathway

New gene name	Prior gene name	Protein domain encoded

trpAa	trpE	Anthranilate synthase: aminase subunit (α)
trpAb	trpG	Anthranilate synthase: amidotransferase subunit (β)
trpB	trpD	Anthranilate phosphoribosyl transferase
trpC	trpF	Phosphoribosyl-anthranilate isomerase
trpD	trpC	Indoleglycerol phosphate synthase
trpEa	trpA	Tryptophan synthase, α subunit
trpEb	trpB	Tryptophan synthase, β subunit

^a The nomenclature is at the level of catalytic domain in the order of reaction steps in the pathway. See [Ref] for a detailed rationale supporting the new nomenclature. Overall reactions of tight complexes are assigned one capital letter, with α and β subunits assigned the corresponding lowercase 'a' and 'b' respectively. The convention of a bullet denotes a fusion, for example, trpD•trpC.

L O S A L A M O S N A T I O N A L L A B O R A T O R Y • Est 1943
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