Rules of Nomenclature
  

The TyrA family includes enzymes with four specificities for the cyclohexadiencyl substrate. PapC participates in antibiotic synthesis and utilizes the 4-amino derivative of prephenate (PPA) as substrate. It can be recognized by its lack of an otherwise invariant residue that interacts with the 4-hydroxy substituent of the cyclohexadienyl substrate in the other three classes. The remaining three classes are alternative dehydrogenase reactions of TYR biosynthesis. TyrAa and TyrAp are specific for AGN and PPA, respectively. TyrAc enzymes have broad specificity and can recognize both AGN and PPA to various extents. A distinct variation of the TyrAc class, denoted as TyrAc_Δ, possesses deletion indels within the catalytic core region. Members of the known substrate-specificity types do not separate into cohesive phylogenetic subgroups, and no obvious discriminating motifs have been found.

Go to TyrA Substrate Specificity Predictor

 Abbreviations used to designate substrate specificities of tyrA/TyrA homologs

Abbreviationa

Description of specificityb

Gene

Gene Product

tyrAx

tyrAc

tyrAp

tyrAc_Δ

tyrAa

TyrAx

TyrAc

TyrAp

TyrAc_Δ

TyrAa

Specificity for cyclohexadienyl substrate is unknown

Broad-specificity cyclohexadienyl dehydrogenase (CDH)

Narrow-specificity prephenate dehydrogenase (PDH)

Broad-specificity cyclohexadienyl dehydrogenase having catalytic-core indels in correlation with an extra-core extension

Narrow-specificity arogenate dehydrogenase (ADH)

NADtyrAa

NADPtyrAa

NAD(P)tyrAa

xtyrAx

NADTyrAa

NADPTyrAa

NAD(P)TyrAa

xTyrAx

TyrA homolog is AGN-specific and NAD+-specific

TyrA homolog is AGN-specific and NADP+-specific

TyrA homolog is AGN-specific but utilizes either NAD+ or NADP+

Specificity for both the cyclohexadienyl and pyridine nucleotide substrates is unknown

a Abbreviations in the upper-table box indicate the specificities for the cyclohexadienyl substrate. Abbreviations in the lower-table box indicate specificities for both cyclohexadienyl (right subscripts) and pyridine nucleotide substrates (left subscripts). Combinations not shown can be deduced from the examples given, e.g., a TyrA homolog specific for prephenate and NAD+ would be designated NADTyrAp.

b The abbreviations CDH, PDH, and ADH (shown parenthetically) have been used frequently in the literature.



L O S   A L A M O S   N A T I O N A L   L A B O R A T O R Y • Est 1943
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