Functional Reaction^a

Acronyms
for Analog or
Sub-homolog
Types ^b

Query Tags

(gi number)

Organisms

2-Keto-3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase

AroA_Iα

AroA_Iβ

AroA_II

*AroA_II

21646940 

4980844 

81555637 

410486 

Chlorobium tepidum (Ctep) 

Thermotoga maritima (Tmar) 

Helicobacter pylori (Hpyl) 

Lycopersicon esculentum (Lesc) 

2-Keto-3-deoxy-D-manno-octulosonate 8-phosphate (KDOP) synthase ^c

KdsA

67466688

Escherichia coli (Ecol)

2-Amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADTH) synthase

AroA'

1591105

Methanococcus jannaschii (Mjan)

Dehydroquinate synthase I

AroB

*AroB

5822049

18425036

Emericella nidulans (Enid)

Arabidopsis thaliana (Atha)

Dehydroquinate synthase II

AroB'

1591882

Methanococcus jannaschii (Mjan)

Dehydroquinase^d

AroC_I

*AroC_I•

AroC_II

17433709 

15230703 

61219243 

Salmonella typhimurium (Styp) 

Arabidopsis thaliana (Atha) 

Mycobacterium tuberculosis (Mtub) 

Shikimate dehydrogenase^d

AroD

•AroD

16131162

15230703

Escherichia coli  (Ecol)

Arabidopsis thaliana (Atha)

Shikimate kinase

AroE_I

*AroE_I

AroE_II

114199 

30692396 

14194467 

Erwinia chrysanthemi (Echr) 

Arabidopsis thaliana (Atha) 

Methanococcus jannaschii (Mjan) 

Enolpyruvylshikimate-3-phosphate (EPSP) synthase

AroF

*AroF

2506201

15225450

Escherichia coli (Ecol)

Arabidopsis thaliana (Atha)

Chorismate synthase

AroG

*AroG

114183

18402389

Escherichia coli (Ecol)

Arabidopsis thaliana (Atha)

Anthranilate synthase (α subunit)  ^¥

PABA synthase (α subunit) ^¥

TrpAa

*TrpAa

PabAa

*PabAa•

14973317

18410376

16129766

30684045

Streptococcus pneumoniae (Spne)

Arabidopsis thaliana (Atha)

Escherichia coli  (Ecol)

Arabidopsis thaliana (Atha)

Anthranilate synthase  (β subunit) ^¥ 

PABA^e synthase   (β subunit) ^¥ 

PABA synthase // Anthranilate synthase
(β subunit)^¥

TrpAb

*TrpAb

PabAb

•PabAb

PabAb // TrpAb

14973316

21594026

16131239

30684045

129521

Streptococcus pneumoniae (Spne)

Arabidopsis thaliana (Atha)

Escherichia coli  (Ecol)

Arabidopsis thaliana (Atha)

Bacillus subtilis (Bsub)

PABA synthase  (γ subunit); 4-Amino-4-deoxy-chorismate lyase

PabAc

*PabAc

1787338

22327924

Escherichia coli  (Ecol)

Arabidopsis thaliana (Atha)

Anthranilate Phosphoribosyl-transferase

TrpB

*TrpB

14973315

15238711

Streptococcus pneumoniae (Spne)

Arabidopsis thaliana (Atha)

Phosphoribosyl-anthranilate isomerase

PR-5-amino-1-PR-4-imidazole carboxamide // PR-anthranilate isomerase^e

TrpC_I

*TrpC_I

HisD // TrpC_II

14973313 

30680348 

45593458 

Streptococcus pneumoniae (Spne) 

Arabidopsis thaliana (Atha) 

Mycobacterium tuberculosis (Mtub) 

Indoleglycerol-phosphate synthase

TrpD

*TrpD

14973314

15238914

Streptococcus pneumoniae (Spne)

Arabidopsis thaliana (Atha)

Tryptophan synthase (α subunit)

TrpEa_α

*TrpEa_α

TrpEa_β

25291883 

18410104 

004320 

Streptococcus pneumoniae (Spne) 

Arabidopsis thaliana (Atha) 

Sulfolobus sulfataricus (Ssul) 

Tryptophan synthase (β subunit)

TrpEb_α

*TrpEb_α

TrpEb_β

25291905 

15239755 

1004319 

Streptococcus pneumoniae (Spne) 

Arabidopsis thaliana (Atha) 

Sulfolobus sulfataricus (Ssul) 

Chorismate mutase

AroH_I

*AroH_I

AroH_II

AroH_III

*AroH_III

2495875 

14794421 

24212657 

6325317 

18406100

Methanococcus jannaschii (Mjan) 

Pseudomonas aeruginosa (Paer) 

Bacillus subtilis (Bsub) 

Saccharomyces cereviseae (Scer) 

Arabidopsis thaliana (Atha) 

Arogenate dehydrogenase^¥

Prephenate dehydrogenase^¥

Cyclohexadienyl dehydrogenase^¥

TyrA_a

*TyrA_a

TyrA_p•ACT

TyrA_c

62389124 

15218283 

143815 

56551316 

Corynebacterium glutamicus (Cglu) 

Arabidopsis thaliana (Atha) 

Bacillus subtilis (Bsub) 

Zymomonas mobilis (Zmob) 

  Prephenate dehydratase ^¥

Arogenate dehydratase^¥

Cyclohexadienyl dehydratase

PheA_Ip•ACT

PheA_Ia•ACT

*PheA_Ia•ACT

*PheA_IIc

130048 

58000965 

79317657

2997758 

Bacillus subtilis (Bsub) 

Gluconobacter oxydans (Goxy) 

Arabidopsis thaliana (Atha) 

Pseudomonas aeruginosa (Paer) 

AroJ_Iα

AroJ_Iβ

*AroJ_Iβ

AroJ_Iγ

85676806 

1574093 

14794424 

6318592 

Escherichia coli (Ecol) 

Haemophilus influenzae (Hinf) 

Pseudomonas aeruginosa (Paer) 

Lactococcus lactis (Llac) 

^aEnzymes in a box that are marked with the symbol ^¥ following the name currently cannot be distinguished from one another with great confidence using the query-tag sequences given.

^bSpacing within a box indicates distinctly separated analog or sub-homolog groupings, with the exception of what is covered in footnote^a.  Asterisk superscripts indicate signal peptides in prokaryotes, whereas green asterisk superscripts indicate transit peptides in higher plants.

^cUse this query to assure that a putative AroA_Iβ sequence is not in fact a KdsA sequence.

^dThe convention of a bullet indicates the fusion of  the two indicated domains  in *AroC_I•AroD proteins of higher plants.

^eAbbreviations:  PABA, 4-aminobenzoate; PR, phosphoribosyl.